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KMID : 1225720200120030399
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Allergy, Asthma & Immunology Research : AAIR
2020 Volume.12 No. 3 p.399 ~ p.411
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Understanding the Molecular Mechanisms of Asthma through Transcriptomics
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Park Heung-Woo
Weiss Scott T.
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Abstract
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The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk RNA sequencing, as well as recent advances in biostatistics based on machine learning approaches provides a quick and effective way of identifying novel genes and pathways related to asthma, which is a heterogeneous disease with diverse pathophysiological mechanisms. In this manuscript, we briefly review how to analyze transcriptome data and then provide a summary of recent transcriptome studies focusing on asthma pathogenesis and asthma drug responses. Studies reviewed here are classified into 2 classes based on the tissues utilized: blood and airway cells.
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KEYWORD
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Asthma, genetics, transcriptome, etiology
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